InnateDB Protein
|
IDBP-99355.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
USP1
|
Protein Name
|
ubiquitin specific peptidase 1
|
Synonyms
|
UBP;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000360188
|
InnateDB Gene
|
IDBG-99353 (USP1)
|
Protein Structure
|
|
Function |
Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. {ECO:0000269PubMed:15694335, ECO:0000269PubMed:16531995, ECO:0000269PubMed:18082604}.
|
Subcellular Localization |
Nucleus {ECO:0000269PubMed:15694335}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
50
[view]
|
Protein-Protein |
44
[view]
|
Protein-DNA |
6
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001394
Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR028889
Ubiquitin carboxyl-terminal hydrolase-like domain
|
PFAM |
PF00443
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O94782
|
PhosphoSite |
PhosphoSite-O94782
|
TrEMBL |
C9JWX4
|
UniProt Splice Variant |
|
Entrez Gene |
7398
|
UniGene |
Hs.35086
|
RefSeq |
NP_001017416
|
HUGO |
HGNC:12607
|
OMIM |
603478
|
CCDS |
CCDS621
|
HPRD |
04593
|
IMGT |
|
EMBL |
AB014458
AB208893
AC096946
AF117386
AL117503
AL117575
BC018745
BC032364
BC050525
CH471059
|
GenPept |
AAD11441
AAH18745
AAH32364
AAH50525
BAA34703
BAD92130
CAB55967
CAB55999
EAX06585
EAX06586
|
|
|