InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: USP1

Summary

InnateDB Protein

IDBP-99357.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP1

Protein Name

ubiquitin specific peptidase 1

Synonyms

UBP;

Species

Homo sapiens

Ensembl Protein

ENSP00000343526

InnateDB Gene

IDBG-99353 (USP1)

Protein Structure

UniProt Annotation

Function

Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. {ECO:0000269PubMed:15694335, ECO:0000269PubMed:16531995, ECO:0000269PubMed:18082604}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15694335}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.

Experimentally validated
Total	50 [view]
Protein-Protein	44 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0001501	skeletal system development
GO:0006281	DNA repair
GO:0006282	regulation of DNA repair
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0009411	response to UV
GO:0016579	protein deubiquitination
GO:0035520	monoubiquitinated protein deubiquitination