InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANGPTL3

Summary

InnateDB Protein

IDBP-99369.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANGPTL3

Protein Name

angiopoietin-like 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000360170

InnateDB Gene

IDBG-99367 (ANGPTL3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Hypobetalipoproteinemia, familial, 2 (FHBL2) [MIM:605019]: A disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Affected individuals present with combined hypolipidemia, consisting of extremely low plasma levels of LDL cholesterol, HDL cholesterol, and triglycerides. {ECO:0000269PubMed:20942659}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed principally in liver. Weakly expressed in kidney. {ECO:0000269PubMed:10644446}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0004859	phospholipase inhibitor activity
GO:0005178	integrin binding
GO:0008083	growth factor activity

Biological Process

GO:0006071	glycerol metabolic process
GO:0006631	fatty acid metabolic process
GO:0006644	phospholipid metabolic process
GO:0007160	cell-matrix adhesion
GO:0007165	signal transduction
GO:0007229	integrin-mediated signaling pathway
GO:0008203	cholesterol metabolic process
GO:0009395	phospholipid catabolic process
GO:0009725	response to hormone
GO:0010519	negative regulation of phospholipase activity
GO:0019915	lipid storage
GO:0030335	positive regulation of cell migration
GO:0042632	cholesterol homeostasis
GO:0045766	positive regulation of angiogenesis
GO:0048844	artery morphogenesis
GO:0050996	positive regulation of lipid catabolic process
GO:0051005	negative regulation of lipoprotein lipase activity
GO:0055088	lipid homeostasis
GO:0055090	acylglycerol homeostasis
GO:0055091	phospholipid homeostasis
GO:0070328	triglyceride homeostasis