InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: JAK1

Summary

InnateDB Protein

IDBP-99445.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

JAK1

Protein Name

Janus kinase 1

Synonyms

JAK1A; JAK1B; JTK3;

Species

Homo sapiens

Ensembl Protein

ENSP00000343204

InnateDB Gene

IDBG-99443 (JAK1)

Protein Structure

UniProt Annotation

Function

Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. {ECO:0000269PubMed:11909529}.

Subcellular Localization

Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.

Disease Associations

Tissue Specificity

Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. {ECO:0000269PubMed:7896447}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 115 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	115 [view]
Protein-Protein	115 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005131	growth hormone receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019903	protein phosphatase binding
GO:0031730	CCR5 chemokine receptor binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007167	enzyme linked receptor protein signaling pathway
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0035556	intracellular signal transduction
GO:0038110	interleukin-2-mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0046677	response to antibiotic
GO:0046777	protein autophosphorylation
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060334	regulation of interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway
GO:0060338	regulation of type I interferon-mediated signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0012505	endomembrane system
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000299 FERM domain
IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR020776 Tyrosine-protein kinase, non-receptor Jak1

PFAM

PF00069
PF00017
PF14633
PF07714
PF00373

PRINTS

PR00401
PR00109
PR01823
PR01824

PIRSF

PIRSF000636

SMART

SM00252
SM00220
SM00295
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References