InnateDB Protein
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IDBP-99584.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GADD45A
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Protein Name
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growth arrest and DNA-damage-inducible, alpha
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Synonyms
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DDIT1; GADD45;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000360024
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InnateDB Gene
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IDBG-99580 (GADD45A)
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Protein Structure
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Function |
In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:7973727}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 139 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
139
[view]
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Protein-Protein |
127
[view]
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Protein-DNA |
9
[view]
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Protein-RNA |
0
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DNA-DNA |
3
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004038
Ribosomal protein L7Ae/L30e/S12e/Gadd45
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PFAM |
PF01248
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P24522
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PhosphoSite |
PhosphoSite-P24522
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
1647
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UniGene |
Hs.80409
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RefSeq |
NP_001186670
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HUGO |
HGNC:4095
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OMIM |
126335
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CCDS |
CCDS55605
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HPRD |
00528
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IMGT |
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EMBL |
AK314991
AL136120
AY135686
BC011757
CH471059
DQ008445
L24498
M60974
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GenPept |
AAA35863
AAA72045
AAH11757
AAM88884
AAY25021
BAG37487
CAI23494
CAI23495
EAX06487
EAX06488
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