InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NEGR1

Summary

InnateDB Protein

IDBP-99702.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NEGR1

Protein Name

neuronal growth regulator 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000350364

InnateDB Gene

IDBG-99700 (NEGR1)

Protein Structure

UniProt Annotation

Function

May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007626	locomotory behavior
GO:0007631	feeding behavior
GO:0010976	positive regulation of neuron projection development
GO:0016337	single organismal cell-cell adhesion

Cellular Component

GO:0005886	plasma membrane
GO:0031225	anchored component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7Z3B1