Version 5.4
Homo sapiens Protein: RABGGTB
Summary
InnateDB Protein IDBP-99773.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RABGGTB
Protein Name Rab geranylgeranyltransferase, beta subunit
Synonyms GGTB;
Species Homo sapiens
Ensembl Protein ENSP00000317473
InnateDB Gene IDBG-99771 (RABGGTB)
Protein Structure
UniProt Annotation
Function Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004663 Rab geranylgeranyltransferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0017137 Rab GTPase binding
Biological Process
GO:0006464 cellular protein modification process
GO:0007601 visual perception
GO:0018344 protein geranylgeranylation
Cellular Component
GO:0005968 Rab-protein geranylgeranyltransferase complex
Protein Structure and Domains
PDB ID
InterPro IPR001330 Prenyltransferase/squalene oxidase
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
PFAM PF00432
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P53611
PhosphoSite PhosphoSite-P53611
TrEMBL Q6IB63
UniProt Splice Variant
Entrez Gene 692085
UniGene Hs.608922
RefSeq NP_004573
HUGO HGNC:9796
OMIM 179080
CCDS CCDS669
HPRD 01532
IMGT
EMBL AL357314 BC020790 CH471059 CR456941 U49245 X98001 Y08201
GenPept AAA91473 AAH20790 CAA66638 CAA69383 CAG33222 EAX06394 EAX06397 EAX06398

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca