InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MSH4

Summary

InnateDB Protein

IDBP-99782.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MSH4

Protein Name

mutS homolog 4 (E. coli)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000263187

InnateDB Gene

IDBG-99780 (MSH4)

Protein Structure

UniProt Annotation

Function

Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis.

Subcellular Localization

Disease Associations

Tissue Specificity

Testis and ovary specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008094	DNA-dependent ATPase activity
GO:0030983	mismatched DNA binding

Biological Process

GO:0001541	ovarian follicle development
GO:0006200	ATP catabolic process
GO:0006298	mismatch repair
GO:0007126	meiotic nuclear division
GO:0007129	synapsis
GO:0007131	reciprocal meiotic recombination
GO:0007283	spermatogenesis
GO:0007292	female gamete generation
GO:0045143	homologous chromosome segregation
GO:0051026	chiasma assembly

Cellular Component

GO:0000793	condensed chromosome
GO:0000794	condensed nuclear chromosome
GO:0000795	synaptonemal complex
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000432 DNA mismatch repair protein MutS, C-terminal
IPR007696 DNA mismatch repair protein MutS, core
IPR007860 DNA mismatch repair protein MutS, connector domain
IPR007861 DNA mismatch repair protein MutS, clamp
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00488
PF05192
PF05188
PF05190

PRINTS

PIRSF

SMART

SM00534
SM00533

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O15457