Version 5.4
Homo sapiens Protein: GIPC2
Summary
InnateDB Protein IDBP-99864.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GIPC2
Protein Name GIPC PDZ domain containing family, member 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000359795
InnateDB Gene IDBG-99862 (GIPC2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed at highest levels in ascending colon and at moderate levels in adult kidney. Expressed at low levels in adult pancreas and at very low levels in adult liver. Expression is down-regulated in several primary tumors, such as kidney, colon and rectal tumors. {ECO:0000269PubMed:11836570}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001478 PDZ domain
IPR014756 Immunoglobulin E-set
IPR017379 Uncharacterised conserved protein UCP038083, PDZ
PFAM PF00595
PF13180
PRINTS
PIRSF PIRSF038083
SMART SM00228
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TF65
PhosphoSite PhosphoSite-Q8TF65
TrEMBL
UniProt Splice Variant
Entrez Gene 54810
UniGene Hs.659356
RefSeq NP_060125
HUGO HGNC:18177
OMIM
CCDS CCDS685
HPRD 17040
IMGT
EMBL AB073737 AK000082 BC036075
GenPept AAH36075 BAA90933 BAB84711

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca