InnateDB Protein
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IDBP-99928.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TTLL7
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Protein Name
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tubulin tyrosine ligase-like family, member 7
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000260505
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InnateDB Gene
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IDBG-99920 (TTLL7)
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Protein Structure
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Function |
Polyglutamylase which preferentially modifies beta- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Required for neurite growth (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell projection, cilium {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Perikaryon {ECO:0000250}. Note=In cells with primary cilia, found in both cilia and basal bodies. In neuronal cells, found in dendrites and perikaryon (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in the nervous system including spinal cord, thalamus, hippocampus, hypothalamus and cerebellum. {ECO:0000269PubMed:16901895}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004344
Tubulin-tyrosine ligase/Tubulin polyglutamylase
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PFAM |
PF03133
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6ZT98
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PhosphoSite |
PhosphoSite-Q6ZT98
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
79739
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UniGene |
Hs.636192
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RefSeq |
NP_078962
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HUGO |
HGNC:26242
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OMIM |
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CCDS |
CCDS690
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HPRD |
08013
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IMGT |
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EMBL |
AC104454
AK026686
AK126792
AL138844
AY170843
BC060878
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GenPept |
AAH60878
AAO37763
BAB15526
BAC86695
CAI22725
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