Version 5.4
Homo sapiens Protein: CTBS
Summary
InnateDB Protein IDBP-99987.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTBS
Protein Name chitobiase, di-N-acetyl-
Synonyms CTB;
Species Homo sapiens
Ensembl Protein ENSP00000359664
InnateDB Gene IDBG-99985 (CTBS)
Protein Structure
UniProt Annotation
Function Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase.
Subcellular Localization Lysosome.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004568 chitinase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006032 chitin catabolic process
GO:0009313 oligosaccharide catabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001223 Glycoside hydrolase, family 18, catalytic domain
IPR011583 Chitinase II
IPR017853 Glycoside hydrolase, superfamily
PFAM PF00704
PRINTS
PIRSF
SMART SM00636
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q01459
PhosphoSite PhosphoSite-Q01459
TrEMBL
UniProt Splice Variant
Entrez Gene 1486
UniGene Hs.678773
RefSeq NP_004379
HUGO HGNC:2496
OMIM 600873
CCDS CCDS698
HPRD 02927
IMGT
EMBL AF085700 AF085701 AF085702 AF085703 AF085704 AF085705 AF085706 AL359762 BC126333 BC126335 CH471097 M95767
GenPept AAA35684 AAC35852 AAI26334 AAI26336 CAH70207 EAW73232 EAW73233

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca