Homo sapiens Gene: SRY
Summary
InnateDB Gene IDBG-1.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRY
Gene Name sex determining region Y
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000184895
Encoded Proteins
sex determining region Y
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome Y:2786855-2787699
Strand Reverse strand
Band p11.2
Transcripts
ENST00000383070 ENSP00000372547
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 25 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005516 calmodulin binding
GO:0008134 transcription factor binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007548 sex differentiation
GO:0030154 cell differentiation
GO:0030238 male sex determination
GO:0045893 positive regulation of transcription, DNA-templated
GO:2000020 positive regulation of male gonad development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016607 nuclear speck
Orthologs
No orthologs found for this gene
Pathways
NETPATH
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Regulation of Androgen receptor activity
Cross-References
SwissProt Q05066
TrEMBL A7WPU8 Q6J4J1
UniProt Splice Variant
Entrez Gene 6736
UniGene Hs.1992
RefSeq NM_003140
HUGO HGNC:11311
OMIM 480000
CCDS CCDS14772
HPRD
IMGT
EMBL AM884747 AM884750 AY601852 AY601853 AY601854 AY601855 AY601856 AY601857 AY601859 AY601860 BC074923 BC074924 CH471115 DQ086141 FN568067 FN568068 FN568069 FN568070 FN568071 FN568073 FN568074 FN568075 FN568076 FN568077 FN568078 FN568079 FN568080 FN568081 FN568082 FN568083 FN568084 FN568085 FN568086 FN568087 FN568088 HM241133 HM241136 HM241142 HM362426 JQ811904 JQ811905 JQ811906 JQ811907 JQ811908 JQ811909 JQ811910 JQ811911 JQ811913 JQ811915 JQ811916 JQ811917 JQ811919 JQ811922 JQ811923 JQ811924 JQ811925 JQ811926 JQ811927 JQ811928 JQ811929 JQ811930 JQ811933 JQ811934 KF413436 KF413440 L08063 L10101 L10102 S53156 S56543 X53772 X96421
GenPept AAA16878 AAA60590 AAA60591 AAB25008 AAB25716 AAH74923 AAH74924 AAT39011 AAT39012 AAT39013 AAT39014 AAT39015 AAT39016 AAT39018 AAT39019 AAY88212 ADJ00507 ADJ00510 ADJ00516 ADJ37112 AFG33929 AFG33930 AFG33931 AFG33932 AFG33933 AFG33934 AFG33935 AFG33936 AFG33937 AFG33938 AFG33939 AFG33940 AFG33942 AFG33944 AFG33945 AFG33946 AFG33947 AFG33948 AFG33949 AFG33950 AFG33951 AFG33952 AFG33954 AFG33955 AGZ62969 AGZ62973 CAA37790 CAA65281 CAP05198 CAP05201 CBH40188 CBH40189 CBH40190 CBH40191 CBH40192 CBH40194 CBH40195 CBH40196 CBH40197 CBH40198 CBH40199 CBH40200 CBH40201 CBH40202 CBH40203 CBH40204 CBH40205 CBH40206 CBH40207 CBH40208 CBH40209 EAX02769
RNA Seq Atlas 6736