Version 5.4
Homo sapiens Gene: LPAR3
Summary
InnateDB Gene IDBG-100000.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LPAR3
Gene Name lysophosphatidic acid receptor 3
Synonyms Edg-7; EDG7; GPCR; HOFNH30; LP-A3; LPA3; RP4-678I3
Species Homo sapiens
Ensembl Gene ENSG00000171517
Encoded Proteins
IDBP-100002
lysophosphatidic acid receptor 3
IDBP-386280
lysophosphatidic acid receptor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:84811602-84893213
Strand Reverse strand
Band p22.3
Transcripts
ENST00000370611 ENSP00000359643
ENST00000440886 ENSP00000395389
ENST00000491034
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001965 G-protein alpha-subunit binding
GO:0004930 G-protein coupled receptor activity
GO:0005543 phospholipid binding
GO:0008289 lipid binding
GO:0070915 lysophosphatidic acid receptor activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007268 synaptic transmission
GO:0032060 bleb assembly
GO:0043410 positive regulation of MAPK cascade
GO:0048672 positive regulation of collateral sprouting
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051928 positive regulation of calcium ion transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0030424 axon
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036832
View Gene Order
ENSBTAG00000003791
Not yet available
Pathways
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_18365
Lysosphingolipid and LPA receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
lysophospholipid_pathway
LPA receptor mediated events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.527909 Hs.622268 Hs.674915 Hs.708438 Hs.711460
RefSeq NM_012152 XM_006710542
HUGO
OMIM
CCDS CCDS700
HPRD 05486
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca