Version 5.4
Homo sapiens Gene: MCOLN3
Summary
InnateDB Gene IDBG-100021.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCOLN3
Gene Name mucolipin 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000055732
Encoded Proteins
IDBP-100023
mucolipin 3
IDBP-100029
mucolipin 3
IDBP-100031
mucolipin 3
IDBP-813348
mucolipin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of members of the mucolipin cation channel proteins. Mutation studies of the highly similar protein in mice have shown that the protein is found in cochlea hair cells, and mutant mice show early-onset hearing loss and balance problems. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:85018082-85048499
Strand Reverse strand
Band p22.3
Transcripts
ENST00000370589 ENSP00000359621
ENST00000341115 ENSP00000342698
ENST00000370587 ENSP00000359619
ENST00000474447
ENST00000490600 ENSP00000474024
ENST00000475312
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007626 locomotory behavior
GO:0034220 ion transmembrane transport
GO:0042491 auditory receptor cell differentiation
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036853
View Gene Order
ENSBTAG00000016982
Not yet available
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
REACT_169333
TRP channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8TDD5
TrEMBL B1ANB7 S4R386
UniProt Splice Variant
Entrez Gene 55283
UniGene Hs.535239
RefSeq NM_001253693 NM_018298 XM_005271003 XM_006710750 XM_006710751
HUGO HGNC:13358
OMIM 607400
CCDS CCDS58009 CCDS701
HPRD
IMGT
EMBL AF475085 AK001868 AL358789 CH471097
GenPept AAL84622 BAA91951 CAI14913 CAI14914 EAW73218
RNA Seq Atlas 55283

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca