Version 5.4
Homo sapiens Gene: TGFBR3
Summary
InnateDB Gene IDBG-100244.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TGFBR3
Gene Name transforming growth factor, beta receptor III
Synonyms betaglycan; BGCAN
Species Homo sapiens
Ensembl Gene ENSG00000069702
Encoded Proteins
IDBP-100246
transforming growth factor, beta receptor III
IDBP-100248
transforming growth factor, beta receptor III
IDBP-386705
transforming growth factor, beta receptor III
IDBP-586308
transforming growth factor, beta receptor III
IDBP-595435
transforming growth factor, beta receptor III
IDBP-588994
transforming growth factor, beta receptor III
IDBP-598514
transforming growth factor, beta receptor III
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:91680343-91906335
Strand Reverse strand
Band p22.1
Transcripts
ENST00000370399 ENSP00000359426
ENST00000212355 ENSP00000212355
ENST00000417833 ENSP00000395975
ENST00000470600
ENST00000468996
ENST00000465892 ENSP00000432638
ENST00000533089 ENSP00000433477
ENST00000525962 ENSP00000436127
ENST00000532540 ENSP00000434994
ENST00000529608
ENST00000533370
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005114 type II transforming growth factor beta receptor binding
GO:0005160 transforming growth factor beta receptor binding
GO:0005515 protein binding
GO:0005539 glycosaminoglycan binding
GO:0008201 heparin binding
GO:0015026 coreceptor activity
GO:0017134 fibroblast growth factor binding
GO:0030165 PDZ domain binding
GO:0046332 SMAD binding
GO:0048185 activin binding
GO:0050431 transforming growth factor beta binding
GO:0070123 transforming growth factor beta receptor activity, type III
Biological Process
GO:0001568 blood vessel development
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001824 blastocyst development
GO:0001837 epithelial to mesenchymal transition
GO:0001889 liver development
GO:0003007 heart morphogenesis
GO:0006461 protein complex assembly
GO:0006955 immune response
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007181 transforming growth factor beta receptor complex assembly
GO:0010633 negative regulation of epithelial cell migration
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0016049 cell growth
GO:0016477 cell migration
GO:0030509 BMP signaling pathway
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031100 organ regeneration
GO:0032354 response to follicle-stimulating hormone
GO:0034695 response to prostaglandin E
GO:0034699 response to luteinizing hormone stimulus
GO:0035556 intracellular signal transduction
GO:0043393 regulation of protein binding
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051271 negative regulation of cellular component movement
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060021 palate development
GO:0060038 cardiac muscle cell proliferation
GO:0060216 definitive hemopoiesis
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060318 definitive erythrocyte differentiation
GO:0060347 heart trabecula formation
GO:0060389 pathway-restricted SMAD protein phosphorylation
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0034673 inhibin-betaglycan-ActRII complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029287
View Gene Order
ENSBTAG00000024269
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
KEGG
INOH
PID NCI
tgfbrpathway
TGF-beta receptor signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.482390 Hs.739252
RefSeq NM_001195683 NM_001195684 NM_003243 XM_006710867 XM_006710868
HUGO
OMIM
CCDS CCDS30770 CCDS55614
HPRD 02846
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca