Homo sapiens Gene: GLMN
Summary
InnateDB Gene IDBG-100272.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLMN
Gene Name glomulin, FKBP associated protein
Synonyms FAP; FAP48; FAP68; FKBPAP; GLML; GVM; VMGLOM;
Species Homo sapiens
Ensembl Gene ENSG00000174842
Encoded Proteins
glomulin, FKBP associated protein
glomulin, FKBP associated protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:92246402-92298987
Strand Reverse strand
Band p22.1
Transcripts
ENST00000370360 ENSP00000359385
ENST00000495106 ENSP00000436829
ENST00000471465
ENST00000495852 ENSP00000469157
ENST00000463560 ENSP00000468973
ENST00000487911
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
Experimentally validated
Total 28 [view]
Protein-Protein 27 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005171 hepatocyte growth factor receptor binding
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0055105 ubiquitin-protein transferase inhibitor activity
Biological Process
GO:0001570 vasculogenesis
GO:0001843 neural tube closure
GO:0031397 negative regulation of protein ubiquitination
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0040029 regulation of gene expression, epigenetic
GO:0042130 negative regulation of T cell proliferation
GO:0042327 positive regulation of phosphorylation
GO:0042692 muscle cell differentiation
GO:0045086 positive regulation of interleukin-2 biosynthetic process
GO:0050715 positive regulation of cytokine secretion
GO:0072359 circulatory system development
Cellular Component
GO:0005622 intracellular
GO:0031461 cullin-RING ubiquitin ligase complex
GO:0031462 Cul2-RING ubiquitin ligase complex
GO:0031463 Cul3-RING ubiquitin ligase complex
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q92990
TrEMBL
UniProt Splice Variant
Entrez Gene 11146
UniGene Hs.49105
RefSeq NM_053274 XM_005270401
HUGO HGNC:14373
OMIM 601749
CCDS CCDS738
HPRD 03451
IMGT
EMBL AJ302727 AJ302728 AJ302729 AJ302730 AJ302731 AJ302732 AJ302733 AJ302734 AJ302735 AJ347709 AL451010 BC001257 CH471097 U73704
GenPept AAC50908 AAH01257 CAC69882 CAC82938 CAC88124 CAH70761 EAW73098
RNA Seq Atlas 11146