Version 5.4
Homo sapiens Gene: DPH5
Summary
InnateDB Gene IDBG-100546.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPH5
Gene Name DPH5 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000117543
Encoded Proteins
IDBP-100548
DPH5 homolog (S. cerevisiae)
IDBP-100550
DPH5 homolog (S. cerevisiae)
IDBP-387242
DPH5 homolog (S. cerevisiae)
IDBP-485560
DPH5 homolog (S. cerevisiae)
IDBP-812457
diphthamide biosynthesis 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:100989623-101026088
Strand Reverse strand
Band p21.2
Transcripts
ENST00000342173 ENSP00000339630
ENST00000370109 ENSP00000359127
ENST00000370105
ENST00000427040 ENSP00000394364
ENST00000492067
ENST00000488789
ENST00000481871
ENST00000464270
ENST00000466807
ENST00000477293
ENST00000498372
ENST00000488176 ENSP00000418282
ENST00000490732
ENST00000476507
ENST00000481982
ENST00000617698 ENSP00000481189
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004164 diphthine synthase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0008152 metabolic process
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine
GO:0032259 methylation
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033554
View Gene Order
ENSBTAG00000019029
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.440776
RefSeq NM_001077394 NM_001077395 NM_015958 XM_005270939 XM_005270941
HUGO
OMIM
CCDS CCDS41358 CCDS41359
HPRD 13037
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca