Version 5.4
Homo sapiens Gene: STXBP3
Summary
InnateDB Gene IDBG-100704.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STXBP3
Gene Name syntaxin binding protein 3
Synonyms MUNC18-3; MUNC18C; PSP; UNC-18C
Species Homo sapiens
Ensembl Gene ENSG00000116266
Encoded Proteins
IDBP-100706
syntaxin binding protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:108746674-108809526
Strand Forward strand
Band p13.3
Transcripts
ENST00000370008 ENSP00000359025
ENST00000483586
ENST00000469338
ENST00000486601
ENST00000485167
ENST00000495245
ENST00000472099
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017075 syntaxin-1 binding
GO:0019905 syntaxin binding
Biological Process
GO:0006904 vesicle docking involved in exocytosis
GO:0007596 blood coagulation
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0030168 platelet activation
GO:0043312 neutrophil degranulation
GO:0045955 negative regulation of calcium ion-dependent exocytosis
GO:0051291 protein heterooligomerization
GO:0061024 membrane organization
GO:0070527 platelet aggregation
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031091 platelet alpha granule
GO:0042581 specific granule
GO:0070062 extracellular vesicular exosome
GO:0070820 tertiary granule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027882
View Gene Order
ENSBTAG00000007330
Not yet available
Pathways
NETPATH
REACTOME
REACT_1178
Disinhibition of SNARE formation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.530436 Hs.628035 Hs.672813
RefSeq NM_007269
HUGO
OMIM
CCDS CCDS790
HPRD 10517
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca