Homo sapiens Gene: ADORA3
Summary
InnateDB Gene IDBG-101074.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADORA3
Gene Name adenosine A3 receptor
Synonyms A3AR; AD026; bA552M11.5;
Species Homo sapiens
Ensembl Gene ENSG00000121933
Encoded Proteins
adenosine A3 receptor
adenosine A3 receptor
adenosine A3 receptor
adenosine A3 receptor
adenosine A3 receptor
adenosine A3 receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:111483348-111563962
Strand Reverse strand
Band p13.2
Transcripts
ENST00000369717 ENSP00000358731
ENST00000369716 ENSP00000358730
ENST00000241356 ENSP00000241356
ENST00000414219 ENSP00000415646
ENST00000443498 ENSP00000398770
ENST00000442484 ENSP00000406102
ENST00000472933
ENST00000463993
ENST00000495493
ENST00000486342
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001609 G-protein coupled adenosine receptor activity
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0001973 adenosine receptor signaling pathway
GO:0002553 histamine secretion by mast cell
GO:0002687 positive regulation of leukocyte migration
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0008016 regulation of heart contraction
GO:0009611 response to wounding
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0043306 positive regulation of mast cell degranulation
GO:0050729 positive regulation of inflammatory response
GO:0050850 positive regulation of calcium-mediated signaling
GO:0070257 positive regulation of mucus secretion
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0042629 mast cell granule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
Adenosine P1 receptors pathway
GPCR ligand binding pathway
Nucleotide-like (purinergic) receptors pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.281342
RefSeq NM_000677 NM_001081976 NM_020683 XM_005270485 XM_005270486 XM_005270489
HUGO
OMIM
CCDS CCDS41369 CCDS838 CCDS839
HPRD 12424
IMGT
EMBL
GenPept
RNA Seq Atlas