InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADORA3

Summary

InnateDB Gene

IDBG-101074.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADORA3

Gene Name

adenosine A3 receptor

Synonyms

A3AR; AD026; bA552M11.5

Species

Homo sapiens

Ensembl Gene

ENSG00000121933

Encoded Proteins

IDBP-101076

adenosine A3 receptor

IDBP-101078

adenosine A3 receptor

IDBP-101086

adenosine A3 receptor

IDBP-387700

adenosine A3 receptor

IDBP-387701

adenosine A3 receptor

IDBP-387702

adenosine A3 receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:111483348-111563962

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000369717	ENSP00000358731
ENST00000369716	ENSP00000358730
ENST00000241356	ENSP00000241356
ENST00000414219	ENSP00000415646
ENST00000443498	ENSP00000398770
ENST00000442484	ENSP00000406102
ENST00000472933
ENST00000463993
ENST00000495493
ENST00000486342

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001609	G-protein coupled adenosine receptor activity
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0001973	adenosine receptor signaling pathway
GO:0002553	histamine secretion by mast cell
GO:0002687	positive regulation of leukocyte migration
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0008016	regulation of heart contraction
GO:0009611	response to wounding
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0043306	positive regulation of mast cell degranulation
GO:0050729	positive regulation of inflammatory response
GO:0050850	positive regulation of calcium-mediated signaling
GO:0070257	positive regulation of mucus secretion