InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KCND3

Summary

InnateDB Gene

IDBG-101100.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCND3

Gene Name

potassium voltage-gated channel, Shal-related subfamily, member 3

Synonyms

KCND3L; KCND3S; KSHIVB; KV4.3; SCA19; SCA22

Species

Homo sapiens

Ensembl Gene

ENSG00000171385

Encoded Proteins

IDBP-101102

potassium voltage-gated channel, Shal-related subfamily, member 3

IDBP-101104

potassium voltage-gated channel, Shal-related subfamily, member 3

IDBP-101106

potassium voltage-gated channel, Shal-related subfamily, member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:111770662-111989155

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000369697	ENSP00000358711
ENST00000315987	ENSP00000319591
ENST00000302127	ENSP00000306923

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005250	A-type (transient outward) potassium channel activity
GO:0005267	potassium channel activity
GO:0005515	protein binding
GO:0044325	ion channel binding
GO:0046872	metal ion binding

Biological Process

GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0008219	cell death
GO:0034765	regulation of ion transmembrane transport
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071435	potassium ion export
GO:0086009	membrane repolarization

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0030425	dendrite
GO:0042383	sarcolemma
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0097038	perinuclear endoplasmic reticulum

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000040896

View Gene Order

ENSBTAG00000031654

Not yet available

Pathways

NETPATH

REACTOME

REACT_75770

Voltage gated Potassium channels pathway

REACT_13685

Neuronal System pathway

REACT_75908

Potassium Channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.23729 Hs.598765 Hs.666367 Hs.730579 Hs.731722

RefSeq

NM_004980 NM_172198 XM_005270851 XM_006710629 XM_006710630 XM_006710631

HUGO

OMIM

CCDS

CCDS843 CCDS844

HPRD

16104

IMGT

EMBL

GenPept

RNA Seq Atlas