Homo sapiens Gene: KCND3
Summary
InnateDB Gene IDBG-101100.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCND3
Gene Name potassium voltage-gated channel, Shal-related subfamily, member 3
Synonyms KCND3L; KCND3S; KSHIVB; KV4.3; SCA19; SCA22;
Species Homo sapiens
Ensembl Gene ENSG00000171385
Encoded Proteins
potassium voltage-gated channel, Shal-related subfamily, member 3
potassium voltage-gated channel, Shal-related subfamily, member 3
potassium voltage-gated channel, Shal-related subfamily, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:111770662-111989155
Strand Reverse strand
Band p13.2
Transcripts
ENST00000369697 ENSP00000358711
ENST00000315987 ENSP00000319591
ENST00000302127 ENSP00000306923
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005250 A-type (transient outward) potassium channel activity
GO:0005267 potassium channel activity
GO:0005515 protein binding
GO:0044325 ion channel binding
GO:0046872 metal ion binding
Biological Process
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0008219 cell death
GO:0034765 regulation of ion transmembrane transport
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
GO:0071435 potassium ion export
GO:0086009 membrane repolarization
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0030425 dendrite
GO:0042383 sarcolemma
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0097038 perinuclear endoplasmic reticulum
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Neuronal System pathway
Voltage gated Potassium channels pathway
Potassium Channels pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UK17
TrEMBL A0A024R0C6
UniProt Splice Variant
Entrez Gene 3752
UniGene Hs.23729 Hs.598765 Hs.666367 Hs.730579 Hs.731722
RefSeq NM_172198 XM_006710630 NM_004980 XM_006710631 XM_005270851 XM_006710629
HUGO HGNC:6239
OMIM 605411
CCDS CCDS844 CCDS843
HPRD 16104
IMGT
EMBL AF048712 AF048713 AF120491 AF166009 AF166010 AF166011 AF187963 AF187964 AF205856 AF205857 AL049557 AL450997 AL512665 BC113475 BC113477 CH471122
GenPept AAC05121 AAC05122 AAD38898 AAF01044 AAF01045 AAF20924 AAF20925 AAF68177 AAF68178 AAI13476 AAI13478 CAI16956 CAI19096 CAI22711 EAW56511 EAW56512
RNA Seq Atlas 3752