Version 5.4
| Homo sapiens Gene: HIST2H2AA4 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-101988.5 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | HIST2H2AA4 | ||||||||||||||||||
| Gene Name | histone cluster 2, H2aa4 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000203812 | ||||||||||||||||||
| Encoded Proteins |
histone cluster 2, H2aa4
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:149842188-149842736 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q21.2 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Meiotic synapsis pathway
Deposition of new CENPA-containing nucleosomes at the centromere pathway
Packaging Of Telomere Ends pathway
Amyloids pathway
RNA Polymerase I Chain Elongation pathway
RNA Polymerase I Promoter Opening pathway
Meiotic recombination pathway
HATs acetylate histones pathway
Cellular responses to stress pathway
PRC2 methylates histones and DNA pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNA Polymerase I Transcription pathway
Signaling by WNT in cancer pathway
Condensation of Prophase Chromosomes pathway
Signaling by Wnt pathway
Chromosome Maintenance pathway
Nucleosome assembly pathway
Transcriptional regulation by small RNAs pathway
Epigenetic regulation of gene expression pathway
RNA Polymerase I Promoter Clearance pathway
NoRC negatively regulates rRNA expression pathway
Telomere Maintenance pathway
Signal Transduction pathway
SIRT1 negatively regulates rRNA Expression pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
HDACs deacetylate histones pathway
DNA methylation pathway
M Phase pathway
Cellular Senescence pathway
TCF dependent signaling in response to WNT pathway
Chromatin organization pathway
Mitotic Prophase pathway
RMTs methylate histone arginines pathway
Chromatin modifying enzymes pathway
Cell Cycle, Mitotic pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
formation of the beta-catenin:TCF transactivating complex pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Meiosis pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Oxidative Stress Induced Senescence pathway
Gene Expression pathway
Disease pathway
Negative epigenetic regulation of rRNA expression pathway
Regulatory RNA pathways pathway
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| KEGG |
Systemic lupus erythematosus pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.530461 Hs.741531 | ||||||||||||||||||
| RefSeq | NM_003516 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS934 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||