Version 5.4
| Homo sapiens Gene: HIST2H2BE | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-101997.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | HIST2H2BE | ||||||||||||||||||
| Gene Name | histone cluster 2, H2be | ||||||||||||||||||
| Synonyms | GL105; H2B; H2B.1; H2BFQ; H2BGL105; H2BQ | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000184678 | ||||||||||||||||||
| Encoded Proteins |
histone cluster 2, H2be
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:149842204-149886652 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q21.2 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 118 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Meiotic synapsis pathway
Deposition of new CENPA-containing nucleosomes at the centromere pathway
Packaging Of Telomere Ends pathway
Amyloids pathway
RNA Polymerase I Chain Elongation pathway
RNA Polymerase I Promoter Opening pathway
Meiotic recombination pathway
HATs acetylate histones pathway
Cellular responses to stress pathway
PRC2 methylates histones and DNA pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNA Polymerase I Transcription pathway
Signaling by WNT in cancer pathway
Condensation of Prophase Chromosomes pathway
Signaling by Wnt pathway
Chromosome Maintenance pathway
Nucleosome assembly pathway
Transcriptional regulation by small RNAs pathway
Epigenetic regulation of gene expression pathway
RNA Polymerase I Promoter Clearance pathway
NoRC negatively regulates rRNA expression pathway
Telomere Maintenance pathway
Signal Transduction pathway
SIRT1 negatively regulates rRNA Expression pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
HDACs deacetylate histones pathway
DNA methylation pathway
M Phase pathway
Cellular Senescence pathway
TCF dependent signaling in response to WNT pathway
Chromatin organization pathway
Mitotic Prophase pathway
Chromatin modifying enzymes pathway
Cell Cycle, Mitotic pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
formation of the beta-catenin:TCF transactivating complex pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Meiosis pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Oxidative Stress Induced Senescence pathway
Gene Expression pathway
Disease pathway
Negative epigenetic regulation of rRNA expression pathway
Regulatory RNA pathways pathway
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| KEGG |
Systemic lupus erythematosus pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q16778 Q8N257 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 8349 | ||||||||||||||||||
| UniGene | Hs.2178 | ||||||||||||||||||
| RefSeq | NM_003528 | ||||||||||||||||||
| HUGO | HGNC:4760 | ||||||||||||||||||
| OMIM | 601831 615046 | ||||||||||||||||||
| CCDS | CCDS936 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AK091220 AK289725 AL139288 AL591493 AY131979 AY131981 BC005827 BC069193 BC096121 BC098112 BC098289 BC100855 BC100856 BC100857 BC100858 BC107084 BC107085 BC137467 BC137468 CH471098 CH471121 CR541895 M60756 X57985 | ||||||||||||||||||
| GenPept | AAA63192 AAH05827 AAH69193 AAH96121 AAH98112 AAH98289 AAI00856 AAI00857 AAI00858 AAI00859 AAI07085 AAI07086 AAI37468 AAI37469 AAN59961 AAN59962 BAC03613 BAF82414 CAA41051 CAG46693 CAI12568 CAI23330 EAW53605 EAW69879 | ||||||||||||||||||
| RNA Seq Atlas | 8349 | ||||||||||||||||||