Version 5.4
Homo sapiens Gene: E4F1
Summary
InnateDB Gene IDBG-10235.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol E4F1
Gene Name E4F transcription factor 1
Synonyms E4F
Species Homo sapiens
Ensembl Gene ENSG00000167967
Encoded Proteins
IDBP-10237
E4F transcription factor 1
IDBP-752896
IDBP-746953
IDBP-748065
IDBP-750182
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. [provided by RefSeq, Jul 2008]
The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in multiple transcripts encoding different proteins. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:2223566-2235742
Strand Forward strand
Band p13.3
Transcripts
ENST00000301727 ENSP00000301727
ENST00000562589 ENSP00000456005
ENST00000565090 ENSP00000456760
ENST00000564930
ENST00000569796
ENST00000563643
ENST00000567111
ENST00000565413 ENSP00000454652
ENST00000564139 ENSP00000457672
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0016874 ligase activity
GO:0035497 cAMP response element binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006260 DNA replication
GO:0006351 transcription, DNA-templated
GO:0007067 mitotic nuclear division
GO:0008283 cell proliferation
GO:0009794 regulation of mitotic cell cycle, embryonic
GO:0010564 regulation of cell cycle process
GO:0016032 viral process
GO:0016567 protein ubiquitination
GO:0040008 regulation of growth
GO:0071850 mitotic cell cycle arrest
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005819 spindle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024137
View Gene Order
ENSBTAG00000009961
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
p53regulationpathway
p53 pathway
Cross-References
SwissProt
TrEMBL H3BSL4
UniProt Splice Variant
Entrez Gene 1877
UniGene Hs.513268
RefSeq NM_001288778 NM_001288776 NM_004424 XM_005255155 XM_005255156 XM_006720857 XM_006720858
HUGO HGNC:3121
OMIM 603022
CCDS CCDS73809 CCDS32370 CCDS73810
HPRD 04317
IMGT
EMBL AC009065
GenPept
RNA Seq Atlas 1877

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca