InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: THEM4

Summary

InnateDB Gene

IDBG-102449.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

THEM4

Gene Name

thioesterase superfamily member 4

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000159445

Encoded Proteins

IDBP-102451

thioesterase superfamily member 4

IDBP-584691

thioesterase superfamily member 4

IDBP-598244

thioesterase superfamily member 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:151873584-151909808

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000368814	ENSP00000357804
ENST00000471464	ENSP00000431288
ENST00000483207
ENST00000477437
ENST00000489410	ENSP00000433304

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016290	palmitoyl-CoA hydrolase activity

Biological Process

GO:0006631	fatty acid metabolic process
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043491	protein kinase B signaling
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0032587	ruffle membrane