Version 5.4
Homo sapiens Gene: ILF2
Summary
InnateDB Gene IDBG-102762.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ILF2
Gene Name interleukin enhancer binding factor 2, 45kDa
Synonyms NF45; PRO3063
Species Homo sapiens
Ensembl Gene ENSG00000143621
Encoded Proteins
IDBP-102764
interleukin enhancer binding factor 2, 45kDa
IDBP-102766
interleukin enhancer binding factor 2, 45kDa
IDBP-102768
interleukin enhancer binding factor 2, 45kDa
IDBP-812050
interleukin enhancer binding factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is the 45 kDa component of nuclear factor of activated T-cells (NFAT), a heterodimer of 45 kDa and 90 kDa proteins. NFAT is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The complex has been shown to repair DNA breaks by nonhomologous end joining and can also negatively regulate the microRNA processing pathway. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:153661788-153671048
Strand Reverse strand
Band q21.3
Transcripts
ENST00000368684 ENSP00000357673
ENST00000361891 ENSP00000355011
ENST00000368681 ENSP00000357670
ENST00000480213
ENST00000615950 ENSP00000482909
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 225 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 225 [view]
Protein-Protein 223 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006955 immune response
GO:0008152 metabolic process
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001016
View Gene Order
ENSBTAG00000012471
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 3608
UniGene Hs.688332 Hs.75117
RefSeq NM_001267809 NM_004515
HUGO HGNC:6037
OMIM 603181
CCDS CCDS1050 CCDS72919
HPRD 04419
IMGT
EMBL
GenPept
RNA Seq Atlas 3608

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca