Version 5.4
Homo sapiens Gene: NPR1
Summary
InnateDB Gene IDBG-102769.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPR1
Gene Name natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
Synonyms ANPa; ANPRA; GUC2A; GUCY2A; NPRA
Species Homo sapiens
Ensembl Gene ENSG00000169418
Encoded Proteins
IDBP-102771
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:153678637-153693992
Strand Forward strand
Band q21.3
Transcripts
ENST00000368680 ENSP00000357669
ENST00000368677
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004383 guanylate cyclase activity
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0008528 G-protein coupled peptide receptor activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016849 phosphorus-oxygen lyase activity
GO:0016941 natriuretic peptide receptor activity
GO:0017046 peptide hormone binding
GO:0019901 protein kinase binding
GO:0042562 hormone binding
Biological Process
GO:0006182 cGMP biosynthetic process
GO:0006468 protein phosphorylation
GO:0007166 cell surface receptor signaling pathway
GO:0007168 receptor guanylyl cyclase signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007589 body fluid secretion
GO:0008217 regulation of blood pressure
GO:0009190 cyclic nucleotide biosynthetic process
GO:0016525 negative regulation of angiogenesis
GO:0030308 negative regulation of cell growth
GO:0030828 positive regulation of cGMP biosynthetic process
GO:0035556 intracellular signal transduction
GO:0035810 positive regulation of urine volume
GO:0035815 positive regulation of renal sodium excretion
GO:0042312 regulation of vasodilation
GO:0042417 dopamine metabolic process
GO:0043114 regulation of vascular permeability
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050880 regulation of blood vessel size
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027931
View Gene Order
ENSBTAG00000006234
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00230
Purine metabolism pathway
hsa04270
Vascular smooth muscle contraction pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt P16066
TrEMBL
UniProt Splice Variant
Entrez Gene 4881
UniGene Hs.490330 Hs.732032
RefSeq NM_000906 XM_006711342
HUGO HGNC:7943
OMIM 108960
CCDS CCDS1051
HPRD
IMGT
EMBL AB010491 AF190631 AL713889 BC063304 CH471121 EU326310 S72628 X15357
GenPept AAD14112 AAF01340 AAH63304 ACA05918 BAA31199 CAA33417 CAI13613 EAW53284
RNA Seq Atlas 4881

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca