Homo sapiens Gene: HOXA1
Summary
InnateDB Gene IDBG-10280.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOXA1
Gene Name homeobox A1
Synonyms BSAS; HOX1; HOX1F;
Species Homo sapiens
Ensembl Gene ENSG00000105991
Encoded Proteins
homeobox A1
homeobox A1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:27092993-27095996
Strand Reverse strand
Band p15.2
Transcripts
ENST00000355633 ENSP00000347851
ENST00000343060 ENSP00000343246
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 93 [view]
Protein-Protein 86 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007275 multicellular organismal development
GO:0007399 nervous system development
GO:0007605 sensory perception of sound
GO:0007634 optokinetic behavior
GO:0008045 motor neuron axon guidance
GO:0009653 anatomical structure morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0021569 rhombomere 3 development
GO:0021570 rhombomere 4 development
GO:0021571 rhombomere 5 development
GO:0021599 abducens nerve formation
GO:0021612 facial nerve structural organization
GO:0021754 facial nucleus development
GO:0021953 central nervous system neuron differentiation
GO:0030902 hindbrain development
GO:0042472 inner ear morphogenesis
GO:0042473 outer ear morphogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048702 embryonic neurocranium morphogenesis
GO:0048839 inner ear development
GO:0048844 artery morphogenesis
GO:0050795 regulation of behavior
GO:0050890 cognition
GO:0050905 neuromuscular process
GO:0060840 artery development
GO:0060876 semicircular canal formation
GO:0090102 cochlea development
GO:0090103 cochlea morphogenesis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt P49639
TrEMBL E7ERT8
UniProt Splice Variant
Entrez Gene 3198
UniGene Hs.613693
RefSeq NM_005522 NM_153620
HUGO HGNC:5099
OMIM 142955
CCDS CCDS5401 CCDS5402
HPRD
IMGT
EMBL AC004079 AK313514 BC032547 CH236948 CH471073 S79869 S79871 S79910 U10421 U37431
GenPept AAA86954 AAB35423 AAB35424 AAB35425 AAC50248 AAC50249 AAC50250 AAH32547 AAS00374 BAG36294 EAL24228 EAW93861
RNA Seq Atlas 3198