Version 5.4
Homo sapiens Gene: ADAM15
Summary
InnateDB Gene IDBG-103072.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAM15
Gene Name ADAM metallopeptidase domain 15
Synonyms MDC15
Species Homo sapiens
Ensembl Gene ENSG00000143537
Encoded Proteins
IDBP-103074
ADAM metallopeptidase domain 15
IDBP-103076
ADAM metallopeptidase domain 15
IDBP-103078
ADAM metallopeptidase domain 15
IDBP-103080
ADAM metallopeptidase domain 15
IDBP-103082
ADAM metallopeptidase domain 15
IDBP-103084
ADAM metallopeptidase domain 15
IDBP-103086
ADAM metallopeptidase domain 15
IDBP-388806
ADAM metallopeptidase domain 15
IDBP-809013
ADAM metallopeptidase domain 15
IDBP-589923
ADAM metallopeptidase domain 15
IDBP-602206
ADAM metallopeptidase domain 15
IDBP-588904
ADAM metallopeptidase domain 15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:155050566-155062775
Strand Forward strand
Band q21.3
Transcripts
ENST00000356955 ENSP00000349436
ENST00000355956 ENSP00000348227
ENST00000271836 ENSP00000271836
ENST00000368413 ENSP00000357398
ENST00000359280 ENSP00000352226
ENST00000368412 ENSP00000357397
ENST00000360674 ENSP00000353892
ENST00000449910 ENSP00000403843
ENST00000447332 ENSP00000476000
ENST00000473905
ENST00000480331
ENST00000477533
ENST00000485346
ENST00000487956
ENST00000472434
ENST00000470779
ENST00000498481
ENST00000461234
ENST00000474709
ENST00000462116
ENST00000468053
ENST00000464824
ENST00000461564
ENST00000533732
ENST00000527418
ENST00000529473 ENSP00000434227
ENST00000526491 ENSP00000432347
ENST00000531703
ENST00000531831
ENST00000531455 ENSP00000432927
ENST00000534019
ENST00000525020
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 50 [view]
Protein-Protein 50 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0017124 SH3 domain binding
Biological Process
GO:0001525 angiogenesis
GO:0006508 proteolysis
GO:0007160 cell-matrix adhesion
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0042246 tissue regeneration
GO:0060317 cardiac epithelial to mesenchymal transition
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0016021 integral component of membrane
GO:0042995 cell projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028041
View Gene Order
ENSBTAG00000010663
Not yet available
Pathways
NETPATH
REACTOME
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
KEGG
INOH
PID NCI
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.312098
RefSeq NM_001261464 NM_001261465 NM_001261466 NM_003815 NM_207191 NM_207194 NM_207195 NM_207196 NM_207197
HUGO
OMIM
CCDS CCDS1084 CCDS1085 CCDS1086 CCDS1087 CCDS1088 CCDS44236 CCDS58031 CCDS58032 CCDS60282
HPRD 05674
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca