Version 5.4
Homo sapiens Gene: RIT1
Summary
InnateDB Gene IDBG-103321.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RIT1
Gene Name Ras-like without CAAX 1
Synonyms NS8; RIBB; RIT; ROC1
Species Homo sapiens
Ensembl Gene ENSG00000143622
Encoded Proteins
IDBP-103323
Ras-like without CAAX 1
IDBP-103325
Ras-like without CAAX 1
IDBP-807382
Ras-like without CAAX 1
IDBP-594969
Ras-like without CAAX 1
IDBP-807384
Ras-like without CAAX 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:155897808-155911404
Strand Reverse strand
Band q22
Transcripts
ENST00000368323 ENSP00000357306
ENST00000368322 ENSP00000357305
ENST00000461050 ENSP00000476319
ENST00000462687
ENST00000539040 ENSP00000441950
ENST00000609492 ENSP00000476612
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0015031 protein transport
GO:0048011 neurotrophin TRK receptor signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028057
View Gene Order
ENSBTAG00000000105
Not yet available
Pathways
NETPATH
REACTOME
REACT_12077
Signalling to p38 via RIT and RIN pathway
REACT_11061
Signalling by NGF pathway
REACT_111102
Signal Transduction pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
KEGG
INOH
PID NCI
mapktrkpathway
Trk receptor signaling mediated by the MAPK pathway
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.491234 Hs.597041 Hs.707578 Hs.708609
RefSeq NM_001256820 NM_001256821 NM_006912
HUGO
OMIM
CCDS CCDS1123 CCDS58036 CCDS58037
HPRD 10195
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca