Homo sapiens Gene: ABCA3
Summary
InnateDB Gene IDBG-10371.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABCA3
Gene Name ATP-binding cassette, sub-family A (ABC1), member 3
Synonyms ABC-C; ABC3; EST111653; LBM180; SMDP3;
Species Homo sapiens
Ensembl Gene ENSG00000167972
Encoded Proteins
ATP-binding cassette, sub-family A (ABC1), member 3
ATP-binding cassette, sub-family A (ABC1), member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The full transporter encoded by this gene may be involved in development of resistance to xenobiotics and engulfment during programmed cell death. [provided by RefSeq, Jul 2008]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The full transporter encoded by this gene may be involved in development of resistance to xenobiotics and engulfment during programmed cell death. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:2275881-2340746
Strand Reverse strand
Band p13.3
Transcripts
ENST00000382381 ENSP00000371818
ENST00000301732 ENSP00000301732
ENST00000563623
ENST00000566200
ENST00000567910 ENSP00000454397
ENST00000569062
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
Biological Process
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0042493 response to drug
GO:0055085 transmembrane transport
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0097208 alveolar lamellar body
GO:0097233 alveolar lamellar body membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
ABCA transporters in lipid homeostasis pathway
ABC-family proteins mediated transport pathway
KEGG
ABC transporters pathway
INOH
PID BIOCARTA
PID NCI
Validated nuclear estrogen receptor alpha network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.26630
RefSeq NM_001089
HUGO
OMIM
CCDS CCDS10466
HPRD 03369
IMGT
EMBL
GenPept
RNA Seq Atlas