Homo sapiens Gene: CD1A
Summary
InnateDB Gene IDBG-103736.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD1A
Gene Name CD1a molecule
Synonyms CD1; FCB6; HTA1; R4; T6;
Species Homo sapiens
Ensembl Gene ENSG00000158477
Encoded Proteins
CD1a molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:158254137-158258269
Strand Forward strand
Band q23.1
Transcripts
ENST00000289429 ENSP00000289429
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0010008 endosome membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
Hematopoietic cell lineage pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.1309
RefSeq NM_001763
HUGO
OMIM
CCDS CCDS1174
HPRD 01776
IMGT
EMBL
GenPept
RNA Seq Atlas