Homo sapiens Gene: CD1C
Summary
InnateDB Gene IDBG-103739.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD1C
Gene Name CD1c molecule
Synonyms BDCA1; CD1; CD1A; R7;
Species Homo sapiens
Ensembl Gene ENSG00000158481
Encoded Proteins
CD1c molecule
CD1c molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:158289786-158293630
Strand Forward strand
Band q23.1
Transcripts
ENST00000368170 ENSP00000357152
ENST00000443761 ENSP00000408755
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030883 endogenous lipid antigen binding
GO:0030884 exogenous lipid antigen binding
GO:0051861 glycolipid binding
GO:0071723 lipopeptide binding
Biological Process
GO:0002286 T cell activation involved in immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0010008 endosome membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
Hematopoietic cell lineage pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 911
UniGene Hs.132448
RefSeq NM_001765
HUGO HGNC:1636
OMIM 188340
CCDS CCDS1175
HPRD 01772
IMGT
EMBL
GenPept
RNA Seq Atlas 911