Version 5.4
Homo sapiens Gene: KCNJ9
Summary
InnateDB Gene IDBG-103981.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNJ9
Gene Name potassium inwardly-rectifying channel, subfamily J, member 9
Synonyms GIRK3; KIR3.3
Species Homo sapiens
Ensembl Gene ENSG00000162728
Encoded Proteins
IDBP-103983
potassium inwardly-rectifying channel, subfamily J, member 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:160081570-160090563
Strand Forward strand
Band q23.2
Transcripts
ENST00000368088 ENSP00000357067
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005242 inward rectifier potassium channel activity
GO:0005515 protein binding
GO:0015467 G-protein activated inward rectifier potassium channel activity
GO:0030165 PDZ domain binding
Biological Process
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038026
View Gene Order
ENSBTAG00000024507
Not yet available
Pathways
NETPATH
REACTOME
REACT_25004
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway
REACT_25031
GABA B receptor activation pathway
REACT_75831
Activation of G protein gated Potassium channels pathway
REACT_13685
Neuronal System pathway
REACT_25199
GABA receptor activation pathway
REACT_75780
G protein gated Potassium channels pathway
REACT_25330
Activation of GABAB receptors pathway
REACT_75918
Inwardly rectifying K+ channels pathway
REACT_75908
Potassium Channels pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q92806
TrEMBL
UniProt Splice Variant
Entrez Gene 3765
UniGene Hs.436567 Hs.66726
RefSeq NM_004983 XM_006711305 XM_006711306
HUGO HGNC:6270
OMIM 600932
CCDS CCDS1194
HPRD
IMGT
EMBL AF193615 AL121987 U52152
GenPept AAB07043 AAF89098 CAI15268
RNA Seq Atlas 3765

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca