InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: F11R

Summary

InnateDB Gene

IDBG-104131.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

F11R

Gene Name

F11 receptor

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000158769

Encoded Proteins

IDBP-104137

F11 receptor

IDBP-104141

F11 receptor

IDBP-806302

Uncharacterized protein

IDBP-598545

F11 receptor

IDBP-812775

F11 receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:160995211-161021348

Strand

Reverse strand

Band

q23.3

Transcripts

ENST00000368026	ENSP00000357005
ENST00000335772
ENST00000289779	ENSP00000289779
ENST00000472573
ENST00000470694	ENSP00000473373
ENST00000537746	ENSP00000440812
ENST00000602966
ENST00000621309	ENSP00000481591

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	18 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	1 [view]

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006954	inflammatory response
GO:0007155	cell adhesion
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007596	blood coagulation
GO:0009314	response to radiation
GO:0016032	viral process
GO:0030154	cell differentiation
GO:0030198	extracellular matrix organization
GO:0030855	epithelial cell differentiation
GO:0034329	cell junction assembly
GO:0045216	cell-cell junction organization
GO:0045777	positive regulation of blood pressure
GO:0050900	leukocyte migration
GO:0070830	tight junction assembly

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0015630	microtubule cytoskeleton
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0031410	cytoplasmic vesicle
GO:0036057	slit diaphragm
GO:0070062	extracellular vesicular exosome