Homo sapiens Gene: HOXA5
Summary
InnateDB Gene IDBG-10422.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOXA5
Gene Name homeobox A5
Synonyms HOX1; HOX1.3; HOX1C;
Species Homo sapiens
Ensembl Gene ENSG00000106004
Encoded Proteins
homeobox A5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:27141052-27143668
Strand Reverse strand
Band p15.2
Transcripts
ENST00000222726 ENSP00000222726
ENST00000520854
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 13 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001501 skeletal system development
GO:0002009 morphogenesis of an epithelium
GO:0003016 respiratory system process
GO:0006351 transcription, DNA-templated
GO:0007389 pattern specification process
GO:0007585 respiratory gaseous exchange
GO:0009952 anterior/posterior pattern specification
GO:0010870 positive regulation of receptor biosynthetic process
GO:0016477 cell migration
GO:0016525 negative regulation of angiogenesis
GO:0030324 lung development
GO:0030878 thyroid gland development
GO:0033599 regulation of mammary gland epithelial cell proliferation
GO:0035264 multicellular organism growth
GO:0043065 positive regulation of apoptotic process
GO:0045639 positive regulation of myeloid cell differentiation
GO:0045647 negative regulation of erythrocyte differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048286 lung alveolus development
GO:0048704 embryonic skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0060435 bronchiole development
GO:0060439 trachea morphogenesis
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060480 lung goblet cell differentiation
GO:0060481 lobar bronchus epithelium development
GO:0060484 lung-associated mesenchyme development
GO:0060535 trachea cartilage morphogenesis
GO:0060536 cartilage morphogenesis
GO:0060574 intestinal epithelial cell maturation
GO:0060638 mesenchymal-epithelial cell signaling
GO:0060644 mammary gland epithelial cell differentiation
GO:0060749 mammary gland alveolus development
GO:0060764 cell-cell signaling involved in mammary gland development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt P20719
TrEMBL
UniProt Splice Variant
Entrez Gene 3202
UniGene Hs.655218
RefSeq NM_019102
HUGO HGNC:5106
OMIM 142952
CCDS CCDS5406
HPRD 00840
IMGT
EMBL AC004080 BC013682 BT009744 CH236948 CH471073 CR542256 M26679
GenPept AAA58663 AAH13682 AAP88746 CAG47052 EAL24223 EAW93873
RNA Seq Atlas 3202