Version 5.4
Homo sapiens Gene: SELE
Summary
InnateDB Gene IDBG-104701.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SELE
Gene Name selectin E
Synonyms CD62E; ELAM; ELAM1; ESEL; LECAM2
Species Homo sapiens
Ensembl Gene ENSG00000007908
Encoded Proteins
IDBP-104703
selectin E
IDBP-104713
selectin E
IDBP-104715
selectin E
IDBP-104717
selectin E
IDBP-104719
selectin E
IDBP-807823
selectin E
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 9006914
SELE is upregulated by TNF alpha during inflammatory responses and activated by RELA, NFKB2, JUN and ATF2.
Entrez Gene
Summary The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:169722641-169764705
Strand Reverse strand
Band q24.2
Transcripts
ENST00000333360 ENSP00000331736
ENST00000367777 ENSP00000356751
ENST00000367776 ENSP00000356750
ENST00000367775 ENSP00000356749
ENST00000367774 ENSP00000356748
ENST00000461085
ENST00000609271 ENSP00000476784
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 15 [view]
Protein-DNA 10 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0033691 sialic acid binding
GO:0043274 phospholipase binding
GO:0070492 oligosaccharide binding
Biological Process
GO:0002092 positive regulation of receptor internalization
GO:0002523 leukocyte migration involved in inflammatory response
GO:0002687 positive regulation of leukocyte migration
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007157 heterophilic cell-cell adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007202 activation of phospholipase C activity
GO:0007596 blood coagulation
GO:0019722 calcium-mediated signaling
GO:0030029 actin filament-based process
GO:0032496 response to lipopolysaccharide
GO:0034612 response to tumor necrosis factor
GO:0045087 innate immune response (InnateDB)
GO:0050727 regulation of inflammatory response
GO:0050900 leukocyte migration
GO:0050901 leukocyte tethering or rolling
GO:0070555 response to interleukin-1
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0005905 coated pit
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030863 cortical cytoskeleton
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026582
View Gene Order
ENSBTAG00000007307
Not yet available
Pathways
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_604
Hemostasis pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa05144
Malaria pathway
hsa05143
African trypanosomiasis pathway
INOH
PID NCI
txa2pathway
Thromboxane A2 receptor signaling
atf2_pathway
ATF-2 transcription factor network
reg_gr_pathway
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000450
HUGO
OMIM
CCDS CCDS1283
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca