Version 5.4
Homo sapiens Gene: FMO1
Summary
InnateDB Gene IDBG-104781.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FMO1
Gene Name flavin containing monooxygenase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000010932
Encoded Proteins
IDBP-104783
flavin containing monooxygenase 1
IDBP-104785
flavin containing monooxygenase 1
IDBP-292998
flavin containing monooxygenase 1
IDBP-389616
flavin containing monooxygenase 1
IDBP-813850
flavin containing monooxygenase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jul 2008]
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:171248471-171285978
Strand Forward strand
Band q24.3
Transcripts
ENST00000367750 ENSP00000356724
ENST00000354841 ENSP00000346901
ENST00000402921 ENSP00000385543
ENST00000433267 ENSP00000406982
ENST00000469112
ENST00000459868
ENST00000472893
ENST00000469711
ENST00000617670 ENSP00000481732
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0004499 N,N-dimethylaniline monooxygenase activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0006082 organic acid metabolic process
GO:0006805 xenobiotic metabolic process
GO:0006970 response to osmotic stress
GO:0009404 toxin metabolic process
GO:0017144 drug metabolic process
GO:0032496 response to lipopolysaccharide
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:0070995 NADPH oxidation
Cellular Component
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040181
View Gene Order
ENSBTAG00000021408
Not yet available
Pathways
NETPATH
REACTOME
REACT_13653
FMO oxidises nucleophiles pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
KEGG
hsa00982
Drug metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q01740
TrEMBL
UniProt Splice Variant
Entrez Gene 2326
UniGene Hs.1424
RefSeq NM_001282694 XM_005245037 NM_001282692 NM_001282693 NM_002021 XM_005245038
HUGO HGNC:3769
OMIM 136130
CCDS CCDS60351 CCDS1294
HPRD 00631
IMGT
EMBL AK290113 AK296198 AL021026 AL031274 AL445673 AY879266 BC047129 CH471067 M64082
GenPept AAA52457 AAH47129 AAW56076 BAF82802 BAH12280 CAI21383 CAI22846 EAW90892
RNA Seq Atlas 2326

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca