Homo sapiens Gene: FMO1
Summary
InnateDB Gene IDBG-104781.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FMO1
Gene Name flavin containing monooxygenase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000010932
Encoded Proteins
flavin containing monooxygenase 1
flavin containing monooxygenase 1
flavin containing monooxygenase 1
flavin containing monooxygenase 1
flavin containing monooxygenase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jul 2008]
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:171248471-171285978
Strand Forward strand
Band q24.3
Transcripts
ENST00000367750 ENSP00000356724
ENST00000354841 ENSP00000346901
ENST00000402921 ENSP00000385543
ENST00000433267 ENSP00000406982
ENST00000469112
ENST00000459868
ENST00000472893
ENST00000469711
ENST00000617670 ENSP00000481732
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0004499 N,N-dimethylaniline monooxygenase activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0006082 organic acid metabolic process
GO:0006805 xenobiotic metabolic process
GO:0006970 response to osmotic stress
GO:0009404 toxin metabolic process
GO:0017144 drug metabolic process
GO:0032496 response to lipopolysaccharide
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:0070995 NADPH oxidation
Cellular Component
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
FMO oxidises nucleophiles pathway
Metabolism pathway
Biological oxidations pathway
Phase 1 - Functionalization of compounds pathway
KEGG
Drug metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.1424
RefSeq NM_001282692 NM_001282693 NM_001282694 NM_002021 XM_005245037 XM_005245038
HUGO
OMIM
CCDS CCDS1294 CCDS60351
HPRD 00631
IMGT
EMBL
GenPept
RNA Seq Atlas