Homo sapiens Gene: HMCN1
Summary
InnateDB Gene IDBG-105391.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMCN1
Gene Name hemicentin 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143341
Encoded Proteins
hemicentin 1
hemicentin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a large extracellular member of the immunoglobulin superfamily. A similar protein in C. elegans forms long, fine tracks at specific extracellular sites that are involved in many processes such as stabilization of the germline syncytium, anchorage of mechanosensory neurons to the epidermis, and organization of hemidesmosomes in the epidermis. Mutations in this gene may be associated with age-related macular degeneration. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:185734551-186190949
Strand Forward strand
Band q25.3
Transcripts
ENST00000271588 ENSP00000271588
ENST00000414277 ENSP00000406205
ENST00000485744
ENST00000493413
ENST00000475585
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0007601 visual perception
GO:0050896 response to stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005938 cell cortex
GO:0016020 membrane
GO:0030054 cell junction
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.58877
RefSeq NM_031935
HUGO
OMIM
CCDS CCDS30956
HPRD 06509
IMGT
EMBL
GenPept
RNA Seq Atlas