Version 5.4
Homo sapiens Gene: PTGS2
Summary
InnateDB Gene IDBG-105426.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTGS2
Gene Name prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Synonyms COX-2; COX2; GRIPGHS; hCox-2; PGG/HS; PGHS-2; PHS-2
Species Homo sapiens
Ensembl Gene ENSG00000073756
Encoded Proteins
IDBP-105428
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
IDBP-595610
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18955820
PTGS2 (COX-2) is suppressed through inhibiting the NF-kappaB activation by LPS and this may be associated with the anti-inflammatory effects of L. casei on Raw264.7 cells.
Entrez Gene
Summary Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:186671791-186680427
Strand Reverse strand
Band q31.1
Transcripts
ENST00000367468 ENSP00000356438
ENST00000490885
ENST00000466691
ENST00000559627 ENSP00000454130
ENST00000559800
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 62 [view]
Protein-Protein 38 [view]
Protein-DNA 21 [view]
Protein-RNA 3 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004601 peroxidase activity
GO:0004666 prostaglandin-endoperoxide synthase activity
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0050473 arachidonate 15-lipoxygenase activity
Biological Process
GO:0001516 prostaglandin biosynthetic process
GO:0001525 angiogenesis
GO:0006693 prostaglandin metabolic process
GO:0006928 cellular component movement
GO:0006954 inflammatory response
GO:0006979 response to oxidative stress
GO:0007566 embryo implantation
GO:0007612 learning
GO:0007613 memory
GO:0008217 regulation of blood pressure
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009314 response to radiation
GO:0009750 response to fructose
GO:0010033 response to organic substance
GO:0010042 response to manganese ion
GO:0010226 response to lithium ion
GO:0010243 response to organonitrogen compound
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0010942 positive regulation of cell death
GO:0014070 response to organic cyclic compound
GO:0019233 sensory perception of pain
GO:0019369 arachidonic acid metabolic process
GO:0019371 cyclooxygenase pathway
GO:0019372 lipoxygenase pathway
GO:0030282 bone mineralization
GO:0030728 ovulation
GO:0031394 positive regulation of prostaglandin biosynthetic process
GO:0031622 positive regulation of fever generation
GO:0031915 positive regulation of synaptic plasticity
GO:0032227 negative regulation of synaptic transmission, dopaminergic
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0033280 response to vitamin D
GO:0034097 response to cytokine
GO:0034612 response to tumor necrosis factor
GO:0034644 cellular response to UV
GO:0035633 maintenance of blood-brain barrier
GO:0042127 regulation of cell proliferation
GO:0042346 positive regulation of NF-kappaB import into nucleus
GO:0042493 response to drug
GO:0042633 hair cycle
GO:0042640 anagen
GO:0043065 positive regulation of apoptotic process
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045786 negative regulation of cell cycle
GO:0045907 positive regulation of vasoconstriction
GO:0045986 negative regulation of smooth muscle contraction
GO:0045987 positive regulation of smooth muscle contraction
GO:0046697 decidualization
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050727 regulation of inflammatory response
GO:0050873 brown fat cell differentiation
GO:0051384 response to glucocorticoid
GO:0051926 negative regulation of calcium ion transport
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0055114 oxidation-reduction process
GO:0070542 response to fatty acid
GO:0071260 cellular response to mechanical stimulus
GO:0071318 cellular response to ATP
GO:0071456 cellular response to hypoxia
GO:0071636 positive regulation of transforming growth factor beta production
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090271 positive regulation of fibroblast growth factor production
GO:0090336 positive regulation of brown fat cell differentiation
GO:0090362 positive regulation of platelet-derived growth factor production
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005901 caveola
GO:0043005 neuron projection
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032487
View Gene Order
ENSBTAG00000014127
Not yet available
Pathways
NETPATH
REACTOME
REACT_150422
Synthesis of 15-eicosatetraenoic acid derivatives pathway
REACT_150149
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_11213
Nicotinamide salvaging pathway
REACT_11088
Nicotinate metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_169312
Defective HLCS causes multiple carboxylase deficiency pathway
REACT_169313
Defective MUT causes methylmalonic aciduria mut type pathway
REACT_169316
Defective MMAA causes methylmalonic aciduria type cblA pathway
REACT_169120
Defective TCN2 causes hereditary megaloblastic anemia pathway
REACT_11238
Metabolism of water-soluble vitamins and cofactors pathway
REACT_169280
Defective AMN causes hereditary megaloblastic anemia 1 pathway
REACT_169149
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
REACT_169363
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
REACT_169178
Defective CD320 causes methylmalonic aciduria pathway
REACT_169429
Defects in cobalamin (B12) metabolism pathway
REACT_169169
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
REACT_169238
Defects in biotin (Btn) metabolism pathway
REACT_169403
Defective BTD causes biotidinase deficiency pathway
REACT_169415
Defective GIF causes intrinsic factor deficiency pathway
REACT_169385
Defects in vitamin and cofactor metabolism pathway
REACT_169132
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
REACT_169256
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
REACT_169439
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
REACT_111217
Metabolism pathway
REACT_169318
Defective MMAB causes methylmalonic aciduria type cblB pathway
REACT_116125
Disease pathway
REACT_11193
Metabolism of vitamins and cofactors pathway
KEGG
hsa00590
Arachidonic acid metabolism pathway
hsa04370
VEGF signaling pathway pathway
hsa05222
Small cell lung cancer pathway
hsa05200
Pathways in cancer pathway
hsa05140
Leishmaniasis pathway
INOH
INOH website
Prostaglandin Leukotriene metabolism pathway
PID NCI
tcrcalciumpathway
Calcium signaling in the CD4+ TCR pathway
s1p_s1p1_pathway
S1P1 pathway
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
cmyb_pathway
C-MYB transcription factor network
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.196384
RefSeq NM_000963
HUGO
OMIM
CCDS CCDS1371
HPRD 02599
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca