InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDC73

Summary

InnateDB Gene

IDBG-105487.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC73

Gene Name

cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000134371

Encoded Proteins

IDBP-105493

cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:193122017-193253901

Strand

Forward strand

Band

q31.2

Transcripts

ENST00000367435	ENSP00000356405
ENST00000482484
ENST00000477868

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	89 [view]
Protein-Protein	86 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000993	RNA polymerase II core binding
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001711	endodermal cell fate commitment
GO:0006351	transcription, DNA-templated
GO:0006378	mRNA polyadenylation
GO:0007049	cell cycle
GO:0008285	negative regulation of cell proliferation
GO:0010390	histone monoubiquitination
GO:0016055	Wnt signaling pathway
GO:0019827	stem cell maintenance
GO:0030177	positive regulation of Wnt signaling pathway
GO:0031442	positive regulation of mRNA 3'-end processing
GO:0031648	protein destabilization
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
GO:0033523	histone H2B ubiquitination
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048147	negative regulation of fibroblast proliferation
GO:0050680	negative regulation of epithelial cell proliferation
GO:0071222	cellular response to lipopolysaccharide
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle