|Homo sapiens Gene: CFH|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||complement factor H|
|Synonyms||AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH; FHL1; HF; HF1; HF2; HUS;|
complement factor H
complement factor H
|Useful resources||Stemformatics EHFPI ImmGen|
CFH is a major regulatory protein that down-regulates alternative complement activation.
CFH, a complement regulatory factor, interacts with host cell surfaces as well as C3d part of C3b and plays a major in the distinguishing host from non-host surfaces during the alternative activated complement pathway.
|InnateDB Annotation from Orthologs|
[Mus musculus] Cfh, a complement regulatory factor, interacts with host cell surfaces as well as C3d part of C3b and plays a major in the distinguishing host from non-host surfaces during the alternatively activated complement pathway.
This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011]
|Genomic Location||Chromosome 1:196651878-196747504|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Innate Immune System pathway
Immune System pathway
Regulation of Complement cascade pathway
Complement cascade pathway
Complement and coagulation cascades pathway
Staphylococcus aureus infection pathway
|UniProt Splice Variant|
|RefSeq||NM_000186 XM_006711283 NM_001014975|
|EMBL||AL049744 BC037285 BC110643 BC142699 CH471067 DQ233256 M12383 M65294 U56979 X04697 X07523 Y00716 Z29665|
|GenPept||AAA35948 AAA52013 AAB01987 AAH37285 AAI10644 AAI42700 ABB02180 CAA30403 CAA68704 CAA82763 CAB41739 CAI19672 EAW91260 EAW91261|
|RNA Seq Atlas||3075|