Version 5.4
| Homo sapiens Gene: PPP1R12B | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-105846.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | PPP1R12B | ||||||||||||||||||
| Gene Name | protein phosphatase 1, regulatory subunit 12B | ||||||||||||||||||
| Synonyms | MYPT2; PP1bp55 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000077157 | ||||||||||||||||||
| Encoded Proteins |
protein phosphatase 1, regulatory subunit 12B
protein phosphatase 1, regulatory subunit 12B
protein phosphatase 1, regulatory subunit 12B
protein phosphatase 1, regulatory subunit 12B
protein phosphatase 1, regulatory subunit 12B
protein phosphatase 1, regulatory subunit 12B
protein phosphatase 1, regulatory subunit 12B
protein phosphatase 1, regulatory subunit 12B
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:202348699-202592706 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q32.1 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME | |||||||||||||||||||
| KEGG |
Regulation of actin cytoskeleton pathway
Focal adhesion pathway
Vascular smooth muscle contraction pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.444403 Hs.707749 | ||||||||||||||||||
| RefSeq | NM_001167857 NM_001167858 NM_001197131 NM_002481 NM_032103 NM_032104 XM_005245202 XM_005245206 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS1426 CCDS44294 CCDS44295 CCDS53458 CCDS53459 CCDS73005 | ||||||||||||||||||
| HPRD | 04794 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||