Version 5.4
Homo sapiens Gene: ATP2B4
Summary
InnateDB Gene IDBG-105961.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP2B4
Gene Name ATPase, Ca++ transporting, plasma membrane 4
Synonyms ATP2B2; MXRA1; PMCA4; PMCA4b; PMCA4x
Species Homo sapiens
Ensembl Gene ENSG00000058668
Encoded Proteins
IDBP-105963
ATPase, Ca++ transporting, plasma membrane 4
IDBP-105965
ATPase, Ca++ transporting, plasma membrane 4
IDBP-105969
ATPase, Ca++ transporting, plasma membrane 4
IDBP-105971
ATPase, Ca++ transporting, plasma membrane 4
IDBP-389914
ATPase, Ca++ transporting, plasma membrane 4
IDBP-592992
ATPase, Ca++ transporting, plasma membrane 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:203626561-203744081
Strand Forward strand
Band q32.1
Transcripts
ENST00000357681 ENSP00000350310
ENST00000356729 ENSP00000349165
ENST00000367218 ENSP00000356187
ENST00000341360 ENSP00000340930
ENST00000458092 ENSP00000391150
ENST00000466407
ENST00000484746 ENSP00000433577
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 21 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005388 calcium-transporting ATPase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0017080 sodium channel regulator activity
GO:0019829 cation-transporting ATPase activity
GO:0046872 metal ion binding
GO:0097110 scaffold protein binding
Biological Process
GO:0006810 transport
GO:0006812 cation transport
GO:0007596 blood coagulation
GO:0008152 metabolic process
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation
GO:1902305 regulation of sodium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026463
View Gene Order
ENSBTAG00000014059
Not yet available
Pathways
NETPATH
NetPath_12
BCR pathway
REACTOME
REACT_23765
Reduction of cytosolic Ca++ levels pathway
REACT_23876
Platelet homeostasis pathway
REACT_25149
Ion transport by P-type ATPases pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_23905
Platelet calcium homeostasis pathway
REACT_25300
Ion channel transport pathway
REACT_604
Hemostasis pathway
KEGG
hsa04020
Calcium signaling pathway pathway
hsa04972
Pancreatic secretion pathway
hsa04970
Salivary secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.343522 Hs.627521 Hs.733333
RefSeq NM_001001396 NM_001684
HUGO
OMIM
CCDS CCDS1440 CCDS30977
HPRD 00159
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca