Version 5.4
Homo sapiens Gene: SCUBE1
Summary
InnateDB Gene IDBG-10601.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCUBE1
Gene Name signal peptide, CUB domain, EGF-like 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000159307
Encoded Proteins
IDBP-10605
signal peptide, CUB domain, EGF-like 1
IDBP-10607
signal peptide, CUB domain, EGF-like 1
IDBP-379231
signal peptide, CUB domain, EGF-like 1
IDBP-813539
signal peptide, CUB domain, EGF-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:43197283-43343388
Strand Reverse strand
Band q13.2
Transcripts
ENST00000360835 ENSP00000354080
ENST00000290460 ENSP00000290460
ENST00000449304 ENSP00000395327
ENST00000477991
ENST00000470433
ENST00000461595
ENST00000480833
ENST00000615096 ENSP00000484780
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006954 inflammatory response
GO:0007512 adult heart development
GO:0007596 blood coagulation
GO:0009791 post-embryonic development
GO:0045446 endothelial cell differentiation
GO:0051260 protein homooligomerization
Cellular Component
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0019897 extrinsic component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000016763
View Gene Order
ENSBTAG00000011275
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.133995
RefSeq NM_173050
HUGO
OMIM
CCDS CCDS14048
HPRD 18029
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca