Homo sapiens Gene: DYRK3
Summary
InnateDB Gene IDBG-106254.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DYRK3
Gene Name dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
Synonyms DYRK5; hYAK3-2; RED; REDK;
Species Homo sapiens
Ensembl Gene ENSG00000143479
Encoded Proteins
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:206635536-206684419
Strand Forward strand
Band q32.1
Transcripts
ENST00000367109 ENSP00000356076
ENST00000367108 ENSP00000356075
ENST00000367106 ENSP00000356073
ENST00000441486 ENSP00000410187
ENST00000489878
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030218 erythrocyte differentiation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O43781
TrEMBL Q5SY34
UniProt Splice Variant
Entrez Gene 8444
UniGene Hs.164267
RefSeq XM_006711576 XM_006711577 NM_003582 NM_001004023 XM_005273315 XM_005273316
HUGO HGNC:3094
OMIM 603497
CCDS CCDS31000 CCDS30999
HPRD 04607
IMGT
EMBL AF186773 AF186774 AF327561 AL591846 AY590695 BC015501 CH471100 Y12735
GenPept AAG17028 AAG17029 AAH15501 AAK16443 AAT06103 CAA73266 CAI13539 CAI13541 EAW93533 EAW93534
RNA Seq Atlas 8444