InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL24

Summary

InnateDB Gene

IDBG-106283.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL24

Gene Name

interleukin 24

Synonyms

C49A; FISP; IL10B; MDA7; MOB5; ST16

Species

Homo sapiens

Ensembl Gene

ENSG00000162892

Encoded Proteins

IDBP-106285

interleukin 24

IDBP-106287

interleukin 24

IDBP-106289

interleukin 24

IDBP-246696

interleukin 24

IDBP-475406

interleukin 24

IDBP-809432

interleukin 24

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:206897443-206904139

Strand

Forward strand

Band

q32.1

Transcripts

ENST00000367095	ENSP00000356062
ENST00000294984	ENSP00000294984
ENST00000367093	ENSP00000356060
ENST00000391929	ENSP00000375795
ENST00000491169
ENST00000480741	ENSP00000418933
ENST00000611909	ENSP00000484900

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	8 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0030336	negative regulation of cell migration
GO:0033136	serine phosphorylation of STAT3 protein
GO:0042060	wound healing
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0071222	cellular response to lipopolysaccharide
GO:0071353	cellular response to interleukin-4

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026420

View Gene Order

ENSBTAG00000007851

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04630

Jak-STAT signaling pathway pathway

INOH

PID NCI

il23pathway

IL23-mediated signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.741469

RefSeq

NM_001185156 NM_001185157 NM_001185158 NM_006850

HUGO

OMIM

CCDS

CCDS1471 CCDS53465 CCDS53466 CCDS73021

HPRD

04995

IMGT

EMBL

GenPept

RNA Seq Atlas