Homo sapiens Gene: CD55
Summary
InnateDB Gene IDBG-106331.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD55
Gene Name CD55 molecule, decay accelerating factor for complement (Cromer blood group)
Synonyms CR; CROM; DAF; TC;
Species Homo sapiens
Ensembl Gene ENSG00000196352
Encoded Proteins
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein involved in the regulation of the complement cascade. The encoded glycoprotein is also known as the decay-accelerating factor (DAF); binding of DAF to complement proteins accelerates their decay, disrupting the cascade and preventing damage to host cells. Antigens present on the DAF glycoprotein constitute the Cromer blood group system (CROM). Two alternatively spliced transcripts encoding different proteins have been identified. The predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma component proteins but an alternatively spliced transcript produces a soluble protein present at much lower levels. Additional, alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:207321508-207360966
Strand Forward strand
Band q32.2
Transcripts
ENST00000367067 ENSP00000356034
ENST00000314754 ENSP00000316333
ENST00000343420 ENSP00000340631
ENST00000367064 ENSP00000356031
ENST00000367063 ENSP00000356030
ENST00000391921 ENSP00000375788
ENST00000488171
ENST00000465534
ENST00000476590
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 25 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0004857 enzyme inhibitor activity
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
GO:0006958 complement activation, classical pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007283 spermatogenesis
GO:0009615 response to virus
GO:0030449 regulation of complement activation
GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway
GO:0035743 CD4-positive, alpha-beta T cell cytokine production
GO:0043086 negative regulation of catalytic activity
GO:0043434 response to peptide hormone
GO:0045087 innate immune response
GO:0045730 respiratory burst
GO:0045916 negative regulation of complement activation
GO:0060137 maternal process involved in parturition
GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation
GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016324 apical plasma membrane
GO:0031225 anchored component of membrane
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Signaling by GPCR pathway
Innate Immune System pathway
Signal Transduction pathway
Immune System pathway
Regulation of Complement cascade pathway
Complement cascade pathway
GPCR ligand binding pathway
Class B/2 (Secretin family receptors) pathway
KEGG
Complement and coagulation cascades pathway
Hematopoietic cell lineage pathway
Viral myocarditis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.126517 Hs.609950 Hs.732565
RefSeq NM_000574 NM_001114752 NM_001300902 XM_005273077
HUGO
OMIM
CCDS CCDS31006 CCDS44307 CCDS73022
HPRD 00500
IMGT
EMBL
GenPept
RNA Seq Atlas