InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CD55

Summary

InnateDB Gene

IDBG-106331.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD55

Gene Name

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

Synonyms

CR; CROM; DAF; TC

Species

Homo sapiens

Ensembl Gene

ENSG00000196352

Encoded Proteins

IDBP-106333

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

IDBP-106335

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

IDBP-106337

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

IDBP-106341

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

IDBP-106343

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

IDBP-246712

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein involved in the regulation of the complement cascade. The encoded glycoprotein is also known as the decay-accelerating factor (DAF); binding of DAF to complement proteins accelerates their decay, disrupting the cascade and preventing damage to host cells. Antigens present on the DAF glycoprotein constitute the Cromer blood group system (CROM). Two alternatively spliced transcripts encoding different proteins have been identified. The predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma component proteins but an alternatively spliced transcript produces a soluble protein present at much lower levels. Additional, alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:207321508-207360966

Strand

Forward strand

Band

q32.2

Transcripts

ENST00000367067	ENSP00000356034
ENST00000314754	ENSP00000316333
ENST00000343420	ENSP00000340631
ENST00000367064	ENSP00000356031
ENST00000367063	ENSP00000356030
ENST00000391921	ENSP00000375788
ENST00000488171
ENST00000465534
ENST00000476590

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	25 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding
GO:0008289	lipid binding

Biological Process

GO:0006958	complement activation, classical pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007283	spermatogenesis
GO:0009615	response to virus
GO:0030449	regulation of complement activation
GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway
GO:0035743	CD4-positive, alpha-beta T cell cytokine production
GO:0043086	negative regulation of catalytic activity
GO:0043434	response to peptide hormone
GO:0045087	innate immune response
GO:0045730	respiratory burst
GO:0045916	negative regulation of complement activation
GO:0060137	maternal process involved in parturition
GO:2000516	positive regulation of CD4-positive, alpha-beta T cell activation
GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016324	apical plasma membrane
GO:0031225	anchored component of membrane
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome