Homo sapiens Gene: CD46 | |||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-106372.6 | ||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||
Gene Symbol | CD46 | ||||||||||||||||||||||||||||||||||
Gene Name | CD46 molecule, complement regulatory protein | ||||||||||||||||||||||||||||||||||
Synonyms | AHUS2; MCP; MIC10; TLX; TRA2.10 | ||||||||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000117335 | ||||||||||||||||||||||||||||||||||
Encoded Proteins |
CD46 molecule, complement regulatory protein
CD46 molecule, complement regulatory protein
CD46 molecule, complement regulatory protein
CD46 molecule, complement regulatory protein
CD46 molecule, complement regulatory protein
CD46 molecule, complement regulatory protein
CD46 molecule, complement regulatory protein
CD46 molecule, complement regulatory protein
CD46 molecule, complement regulatory protein
CD46 molecule, complement regulatory protein
CD46 molecule, complement regulatory protein
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Protein Structure | |||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||||||||
Summary |
CD46 is a cell surface pathogen receptor that induces autophagy upon pathogen recognition and this CD46-dependent autophagy is critical for early control of the infection.
CD46 is a ubiquitously expressed membrane protein that regulates complement activation, as a cellular attachment receptor of several pathogens, including measles virus, Neisseria gonorrhea, adenovirus and human herpesvirus 6.
CD46 enhances bacterial survival and represents a novel pathogenic mechanism that contributes to the severity of group A streptococcal disease.
CD46 acts as a human epithelial cell receptor for internalization of opsonized uropathogenic Escherichia coli.
CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells, whereby the complement innate immune system is using two synergistic strategies with the recognition of altered self-nucleic acids (NA) and missing self-CD46 signals to instruct and tailor the efficient removal of apoptotic and necrotic cells in immunoprivileged sites.
CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. CD46 has a vital role in preventing complement deposition on host tissue, and the resulting auto-immunity.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||
Summary |
[Mus musculus] Cd46 enhances nitric oxide production in mouse macrophages in response to measles virus infection in the presence of gamma interferon.
[Mus musculus] Cd46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Cd46 has a vital role in preventing complement deposition on host tissue, and the resulting auto-immunity.
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Entrez Gene | |||||||||||||||||||||||||||||||||||
Summary |
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010] |
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Gene Information | |||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 1:207752057-207795513 | ||||||||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||||||||
Band | q32.2 | ||||||||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||
Species
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||||
REACTOME |
Regulation of Complement cascade pathway
Innate Immune System pathway
Immune System pathway
Complement cascade pathway
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KEGG |
Complement and coagulation cascades pathway
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INOH | |||||||||||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||
UniGene | Hs.510402 | ||||||||||||||||||||||||||||||||||
RefSeq | NM_002389 NM_153826 NM_172350 NM_172351 NM_172352 NM_172353 NM_172359 NM_172361 | ||||||||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||||
CCDS | CCDS1479 CCDS1480 CCDS1481 CCDS1482 CCDS1484 CCDS1485 CCDS31008 CCDS31009 | ||||||||||||||||||||||||||||||||||
HPRD | 00406 | ||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||||||||