Version 5.4
Homo sapiens Gene: DTL
Summary
InnateDB Gene IDBG-106535.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DTL
Gene Name denticleless E3 ubiquitin protein ligase homolog (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143476
Encoded Proteins
IDBP-106537
denticleless homolog (Drosophila)
IDBP-603656
denticleless homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:212035553-212107400
Strand Forward strand
Band q32.3
Transcripts
ENST00000366991 ENSP00000355958
ENST00000475419
ENST00000489149
ENST00000463791
ENST00000496442
ENST00000542077 ENSP00000443870
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
Experimentally validated
Total 55 [view]
Protein-Protein 53 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006260 DNA replication
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
GO:0006974 cellular response to DNA damage stimulus
GO:0009411 response to UV
GO:0019985 translesion synthesis
GO:0031572 G2 DNA damage checkpoint
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0031465 Cul4B-RING E3 ubiquitin ligase complex
GO:0031965 nuclear membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037474
View Gene Order
ENSBTAG00000018142
Not yet available
Cross-References
SwissProt
TrEMBL F5GZ90
UniProt Splice Variant
Entrez Gene 51514
UniGene Hs.606773 Hs.656473
RefSeq NM_001286229 NM_001286230 NM_016448
HUGO HGNC:30288
OMIM 610617
CCDS CCDS65778 CCDS1502
HPRD 17952
IMGT
EMBL AC092814 AL592297 AL606468
GenPept
RNA Seq Atlas 51514

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca