InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EPRS

Summary

InnateDB Gene

IDBG-106727.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPRS

Gene Name

glutamyl-prolyl-tRNA synthetase

Synonyms

EARS; GLUPRORS; PARS; QARS; QPRS

Species

Homo sapiens

Ensembl Gene

ENSG00000136628

Encoded Proteins

IDBP-106729

glutamyl-prolyl-tRNA synthetase

IDBP-806852

glutamyl-prolyl-tRNA synthetase

IDBP-806848

glutamyl-prolyl-tRNA synthetase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:219968601-220046658

Strand

Reverse strand

Band

q41

Transcripts

ENST00000366923	ENSP00000355890
ENST00000468487
ENST00000485821
ENST00000464052
ENST00000477030	ENSP00000477493
ENST00000609181	ENSP00000477245

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	95 [view]
Protein-Protein	94 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004818	glutamate-tRNA ligase activity
GO:0004827	proline-tRNA ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016876	ligase activity, forming aminoacyl-tRNA and related compounds
GO:0035613	RNA stem-loop binding

Biological Process

GO:0006412	translation
GO:0006418	tRNA aminoacylation for protein translation
GO:0006424	glutamyl-tRNA aminoacylation
GO:0006433	prolyl-tRNA aminoacylation
GO:0006461	protein complex assembly
GO:0010467	gene expression
GO:0017148	negative regulation of translation
GO:0043039	tRNA aminoacylation
GO:0071346	cellular response to interferon-gamma

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0097452	GAIT complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026615

View Gene Order

ENSBTAG00000006898

Not yet available

Pathways

NETPATH

NetPath_11

TCR pathway

NetPath_24

TSLP pathway

REACTOME

REACT_15306

Cytosolic tRNA aminoacylation pathway

REACT_15482

tRNA Aminoacylation pathway

REACT_71

Gene Expression pathway

KEGG

hsa00970

Aminoacyl-tRNA biosynthesis pathway

hsa00860

Porphyrin and chlorophyll metabolism pathway

INOH

INOH website

Glutamate Glutamine metabolism pathway

INOH website

Arginine Proline metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.497788 Hs.608579

RefSeq

NM_004446

HUGO

OMIM

CCDS

CCDS31027

HPRD

00703

IMGT

EMBL

GenPept

RNA Seq Atlas